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祝秉东

发布时间:2021-05-12   字体大小T|T

    祝秉东,医学博士,教授,博士生导师。大红鹰dhy官网病原生物学研究所所长/教研室主任,大红鹰dhy官网结核病研究中心常务副主任。入选教育部新世纪优秀人才支持计划(2007年)及受聘甘肃省飞天学者特聘教授(2016年)。中国微生物学会人兽共患病病原学专业委员会疫苗学组副组长,甘肃省免疫学会基础免疫专业委员会主任委员。从事医学微生物、人体寄生虫学的教学和研究工作。参与编写《医学微生物学》(人民卫生出版社,应用型创新规划教材)和《Medical Microbiology》(郑州大学出版社)等多部教材。 从事结核亚单位疫苗及免疫记忆与结核病免疫病理研究。先后主持和参与国家863计划、国家自然科学基金、国家科技重大专项等项目。
联系方式:E-Mail: bdzhu@lzu.edu.cn
主要研究方向:
1.结核亚单位疫苗研究。结核病是我国和世界范围内的重大传染病。已有的结核疫苗BCG对预防儿童严重的粟粒性结核和结核性脑膜炎有效,但其免疫保护作用至成人阶段已有所减弱,缺乏有效的保护作用。为此,课题组主要研究可强化BCG免疫保护效果的亚单位疫苗,以提高成人免疫保护力,最终达到提高人群抗结核免疫保护水平的目的。和兰州生物制品研究所有限责任公司建立了密切合作联系,积极促进疫苗应用转化。
2.结核疫苗免疫与结核病免疫病理机制研究。结核病的免疫保护机制尚不清晰,我们课题组就结核疫苗诱导的免疫记忆、免疫调节等科学问题进行深入研究,以优化疫苗设计,研究疫苗评价的新指标。此外,针对难治性结核,我们开展了结核病免疫耗竭机制及干预措施研究。
3.肿瘤代谢与免疫治疗。和甘肃省人民医院妇产科等单位合作进行宫颈癌糖酵解与免疫调节研究。
代表性文章:
1.Xun Liu#, Fei Li#, Hongxia Niu, Lan Ma, Jianzhu Chen, Ying Zhang, Liang Peng, Chao Gan, Xingming Ma, Bingdong Zhu*. IL-2 restores T-cell dysfunction induced by persistent Mycobacterium tuberculosis antigen stimulation. Front. Immunol. 2019;10:2350 | https://doi.org/10.3389/fimmu.2019.02350
2.Li F, Liu X, Niu H, Lv W, Han X, Zhang Y, Zhu B*. Persistent stimulation with Mycobacterium tuberculosis antigen impairs the proliferation and transcriptional  program of hematopoietic cells in bone marrow. Mol Immunol. 2019 Aug;112:115-122. doi: 10.1016/j.molimm.2019.05.001.
3.Bai C, He J, Niu H, Hu L, Luo Y, Liu X, Peng L, Zhu B*. Prolonged intervals during Mycobacterium tuberculosis subunit vaccine boosting contributes to eliciting immunity mediated by central memory-like T cells. Tuberculosis (Edinb). 2018 May;110:104-111. doi: 10.1016/j.tube.2018.04.006. Epub 2018 Apr 24. PubMed PMID: 29779765.
4.Zhu B*, Dockrell HM, Ottenhoff THM, Evans TG, Zhang Y. Tuberculosis vaccines: Opportunities and challenges. Respirology. 2018 Apr;23(4):359-368. doi:10.1111/resp.13245. Epub 2018 Jan 17. Review. PubMed PMID: 29341430.
5.Liu X, Peng J, Hu L, Luo Y, Niu H, Bai C, Wang Q, Li F, Yu H, Wang B, Chen H, Guo M, Zhu B*. A multistage Mycobacterium tuberculosis subunit vaccine LT70 including latency antigen Rv2626c induces long-term protection against tuberculosis. Hum Vaccin Immunother. 2016;12(7):1670-7. PubMed PMID: 26901244.
6.Liu X, Da Z, Wang Y, Niu H, Li R, Yu H, He S, Guo M, Wang Y, Luo Y, Ma X, Zhu B*. A novel liposome adjuvant DPC mediates Mycobacterium tuberculosis subunit vaccine well to induce cell-mediated immunity and high protective efficacy in mice. Vaccine. 2016;34(11):1370-8. PubMed PMID: 26845736.
7.Luo Y, Ma X, Liu X, Lu X, Niu H, Yu H, Bai C, Peng J, Xian Q, Wang Y, Zhu B*. IL-28B down-regulates regulatory T cells but does not improve the protective immunity following tuberculosis subunit vaccine immunization. Int Immunol. 2016;28(2):77-85.
8.Niu H, Peng J, Bai C, Liu X, Hu L, Luo Y, Wang B, Zhang Y, Chen J, Yu H, Xian Q, Zhu B*. Multi-Stage Tuberculosis Subunit Vaccine Candidate LT69 Provides High Protection against Mycobacterium tuberculosis Infection in Mice. PLoS One. 2015 Jun 22;10(6):e0130641.
9.Liu X, Wang D, Liu H, Feng Y, Zhu T, Zhang L, Zhu B*, Zhang Y*. Knockdown of astrocyte elevated gene-1 (AEG-1) in cervical cancer cells decreases their invasiveness, epithelial to mesenchymal transition, and chemoresistance. Cell Cycle. 2014;13(11):1702-7.
10.Xin Q, Niu H, Li Z, Zhang G, Hu L, Wang B, Li J, Yu H, Liu W, Wang Y, Da Z, Li R, Xian Q, Wang Y, Zhang Y, Jing T, Ma X, Zhu B*. Subunit vaccine consisting of multi-stage antigens has high protective efficacy against Mycobacterium tuberculosis infection in mice. PLoS One. 2013 Aug 15;8(8):e72745.

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