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张宝来

发布时间:2021-05-12   字体大小T|T

张宝来(1973年—),男,汉族,甘肃通渭人。1999年毕业于大红鹰dhy官网医学院临床医学专业,获临床医学学士学位;2005年毕业于大红鹰dhy官网药理学专业,获医学硕士学位;2014年毕业于四川大学药理学专业,获理学博士学位。现为大红鹰dhy官网副教授,药理学专业硕士研究生导师。兼任药理、新药与生化党支部书记,药理学教研室主任。
E-mail:zhangbl@lzu.edu.cn
 
【研究方向】新药药理,肿瘤药理和癌症的表观遗传调控
【主讲课程】《药理学进展》、《药理学》和《药理学实验》
【教材】
主编《药理学实验指导》(普通高等教育“十三五”规划教材),清华大学出版社,2020。
参编《药理学教程》(第七版),高等教育出版社,2021。
【主要荣誉】 时间 荣誉名称
2017 大红鹰dhy官网大学生创新创业行动计划“优秀指导老师”
代表性研究成果(通讯或第1作者)
1. Suyin Ge, Qingqing Zhang, Yonglin Chen, Yizhen Tian, Ruiying Yang, Xu Chen, Fang Li, and Baolai Zhang*. Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol, 2021, 15;415:115450.
2. Suyin Ge, Qingqing Zhang, Yizhen Tian, Luyang Hao, Jingru Duan, Baolai Zhang*. Cell Metabolic Profiling of Colorectal Cancer via 1H NMR. Clin Chim Acta, 2020, 510, 291-297.
3. Yizhen Tian1, Yapeng Liu1, Sanchun Tian, Suyin Ge, Yongjie Wu, Baolai Zhang*. Antitumor activity of ginsenoside Rd in gastric cancer via up-regulation Caspase-3 and Caspase-9. Pharmazie, 2020, 75: 147-150.
4. Baolai Zhang1*, Xue Chen1, Suying Ge, Caili Peng, Su Zhang, Xu Chen, Tao Liu, and Wenkai Zhang. Arginine methyltransferase inhibitor 1 inhibits mouse sarcoma growth in vitro and in vivo. Oncol Lett, 2018, 16, 2161-2166.
5. Shuhong Dong1, Xing Wang1, Sanchun Tian, Nengqian Ma, Xinyang Zhang, Yapeng Liu, Baolai Zhang* and Yongjie Wu*. Arginine methyltransferase inhibitor 1 exhibits antitumor effects against cervical cancer in vitro and in vivo. Pharmazie, 2018, 73: 269–273.
6. Baolai Zhang1,*, Su Zhang1, Lijuan Zhu, Xue Chen, Yunfeng Zhao, Li Chao, Juanping Zhou, Xing Wang, Xinyang Zhang, Nengqian Ma. Arginine methyltransferase inhibitor 1 inhibits gastric cancer by downregulating eIF4E and targeting PRMT5. Toxicol Appl Pharmacol, 2017, 336:1-7.
7. Baolai Zhang, Shuhong Dong, Ruiming Zhu, Chunyan Hu, Jing Hou, Yan Li, Qian Zhao, Xue Shao, Qian Bu, Hongyu Li, Yongjie Wu, Xiaobo Cen* and Yinglan Zhao*. Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3. Oncotarget, 2015, 6 (26):22799-22811.
8. Baolai Zhang1,*, Shuhong Dong1, Zhongxin Li, Li Lu, Su Zhang, Xue Chen, Xiaobo Cen, and Yongjie Wu*. Targeting protein arginine methyltransferase 5 inhibits human hepatocellular carcinoma growth via the downregulation of beta?catenin. J Transl Med, 2015, 13:394.
9. Baolai Zhang, Shuhong Dong, Xiaobo Cen, Xiao Wang, Xia Liu, Hongxia Zhang, Xin Zhao, Yongjie Wu*. Ampelopsin sodium exhibits antitumor effects against bladder carcinoma in orthotopic xenograft models. Anticancer Drugs, 2012, 23 (6):590-96.
10. Baolai Zhang, Bei Gao, Shuhong Dong, Yingqi Zhang, Yongjie Wu*. Anti-tumor efficacy and pre-clinical immunogenicity of IFNa2a-NGR,Regul Toxicol Pharmacol, 2011, 60(1):73–78.
 
研究项目
(项目来源  项目名称  起止时间)
主持企事业单位委托科技项目:生物碱临床前药理药效研究,2019.09-2020.12;
主持企事业单位委托科技项目:藏药新药临床前药理药效研究,2015.12-2019.06;
主持中央高校基本科研业务费:PRMT5沉默对人原发性肝癌的作用及机制研究,2013.01-2014.06;
主持中央高校基本科研业务费:蛇葡萄素钠治疗裸鼠人膀胱癌原位移植瘤的药效学与药动学关系的研究,2009.05-2011.09。

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